45 So when He came to Galilee, the Galileans received Him, having seen all the things that He did in Jerusalem at the feast; for they themselves also went to the feast.” John 4:43-45.
If one drew a straight line from the middle of Samaria, where Jesus talked to the woman at the well in the previous Scripture, to Cana, where we will next read of Jesus healing the nobleman’s son, this line would cross over Nazareth. Accordingly, one could reasonably think that Jesus would stop at Nazareth and spend some time there, Jesus’ hometown where He lived as a boy and grew up. However, at least in this Scripture, nothing is stated at least here about a visit to Nazareth at this time.
In Matthew Chapter 13, we do read about Jesus’ visit to Nazareth, maybe at a different time, although it may be at this same time, which gives us a better understanding of Jesus’ statement: “a prophet has no honor in his own country”.
“53 When Jesus had finished these parables, He departed from there.
54 He came to His hometown and began teaching them in their synagogue, so that they were astonished, and said, “Where did this man get this wisdom and these miraculous powers?
55 “Is not this the carpenter’s son? Is not His mother called Mary, and His brothers, James and Joseph and Simon and Judas?
56 “And His sisters, are they not all with us? Where then did this man get all these things?”
57 And they took offense at Him. But Jesus said to them, “A prophet is not without honor except in his hometown and in his own household.”
58 And He did not do many miracles there because of their unbelief.” Matthew 13:53-58.
So, what is the significance of this John 4:43-45 Scripture?
For some of us, Christians, at some times, we may need to leave the comfort of home to more effectively perform our ministry elsewhere. This Scripture can be of encouragement to us for such times.
We should recognize that there are those who may be called to minister in their hometowns for there entire lives. This Scripture should not bother them. Also, for others, they may be at home for awhile, this Scripture should also not bother them; they should be at peace and enjoy their time at home.
We can and should trust God to place us in the Body of Christ where He wants and when He wants to do it. We should not think necessarily: “Oh, no, I will live the rest of my life in Poduk, Iowa!” (No offense to Poduk, if there is actually such a place. It may be a great place to live. 
As a personal example, I grew up in Muskegon, Michigan, and I still have a lot of good friends in the Muskegon – Grand Rapids area. Although St. Petersburg, Florida, where I live is a great city, I probably would have cried a lot and been miserable around 1977 when I left home to go to law school in St. Petersburg if I allowed myself to think such thoughts.
1 Corinthians 12:18
“But now God has placed the members, each one of them, in the body, just as He desired.”
God gives us all the grace that we need to deal with any situation. 2 Corinthians 12:9 “And He has said to me, “My grace is sufficient for you, for power is perfected in weakness ” Most gladly, therefore, I will rather boast about my weaknesses, so that the power of Christ may dwell in me.”
And, we should not think of this grace as just “bare bones” grace. God does not give the minimum of grace, just enough to get by.
God’s grace is lavish. “He who did not spare His own Son, but delivered Him over for us all, how will He not also with Him freely give us all things?” Romans 9:32. “For the LORD God is a sun and shield; The LORD gives grace and glory; No good thing does He withhold from those who walk uprightly.” Psalm 84:11
In conclusion, it is my personal testimony, after living 33 years many miles away from home, that God has filled my life with so many good things, including wonderful visits back home (with the last time being a September fishing trip to Canada with three of my college buddies). “… the LORD is upright; He is my rock, and there is no unrighteousness in Him.” Psalm 92:15.
Reformed Doctrine Daily Devotions 